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Article

Actionable FGFR1 and BRAF mutations in adult circumscribed gliomas.

Journal of neuro-oncology - 1 Nov 2019

Trisolini Elena, Wardighi Dounia El, Giry Marine, Bernardi Priscilla, Boldorini Renzo Luciano, Mokhtari Karima, Sanson Marc

Abstract excerpt

PURPOSE: Circumscribed gliomas -pilocytic astrocytomas (PA), gangliogliomas (GG), ependymomas (EP)- are mostly low-grade tumours but may progress to anaplasia and sometimes surgery can be challenging due to deep anatomical localization. Because of the high frequency of MAPK-pathway alterations and availability of targeted therapies for FGFR1 and BRAF-mutated tumors, we investigated these mutational hotspots in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31673897
DOI: 10.1007/s11060-019-03306-9

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