Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects.

doi:10.2217/pgs.13.180

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Article

Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects.

Pharmacogenomics - 1 Nov 2013

Kaniwa Nahoko, Sugiyama Emiko, Saito Yoshiro, Kurose Kouichi, Maekawa Keiko, Hasegawa Ryuichi, Furuya Hirokazu, Ikeda Hiroko, Takahashi Yukitoshi, Muramatsu Masaaki, Tohkin Masahiro, Ozeki Takeshi, Mushiroda Taisei, Kubo Michiaki, Kamatani Naoyuki, Abe Masamichi, Yagami Akiko, Ueta Mayumi, Sotozono Chie, Kinoshita Shigeru, Ikezawa Zenro, Matsunaga Kayoko, Aihara Michiko

Abstract excerpt

AIM: This preliminary study investigated genomic biomarkers for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), related to three antiepileptic drugs, zonisamide, phenobarbital and phenytoin. PATIENTS & METHODS: HLA class I and HLA-DRB1 loci were genotyped for Japanese patients with zonisamide-, phenobarbital- or phenytoin-induced SJS/TEN (n = 12, 8 and 9, respectively) and for healthy...

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PMID: 24236482
DOI: 10.2217/pgs.13.180

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