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HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis.

Pharmacogenomics - 1 Nov 2008

Kaniwa Nahoko, Saito Yoshiro, Aihara Michiko, Matsunaga Kayoko, Tohkin Masahiro, Kurose Kouichi, Sawada Jun-ichi, Furuya Hirokazu, Takahashi Yukitoshi, Muramatsu Masaaki, Kinoshita Shigeru, Abe Masamichi, Ikeda Hiroko, Kashiwagi Mariko, Song Yixuan, Ueta Mayumi, Sotozono Chie, Ikezawa Zenro, Hasegawa Ryuichi

Abstract excerpt

INTRODUCTION: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 and HLA-B*5801 with carbamazepine- and allopurinol-induced severe cutaneous adverse reactions were found in Han Chinese patients, respectively, but ethnic differences in the associations have been reported. The objective of...

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Identifiers

PMID: 19018717
DOI: 10.2217/14622416.9.11.1617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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