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Article

Magnesium sulfate protects against the bioenergetic consequences of chronic glutamate receptor stimulation.

PloS one - 1 Jan 2013

Clerc Pascaline, Young Christina A, Bordt Evan A, Grigore Alina M, Fiskum Gary, Polster Brian M

Abstract excerpt

Extracellular glutamate is elevated following brain ischemia or trauma and contributes to neuronal injury. We tested the hypothesis that magnesium sulfate (MgSO4, 3 mM) protects against metabolic failure caused by excitotoxic glutamate exposure. Rat cortical neuron preparations treated in medium already containing a physiological concentration of Mg(2+) (1 mM) could be segregated based on their response to...

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Identifiers

PMID: 24236167
DOI: 10.1371/journal.pone.0079982
PMCID: PMC3827425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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