Article
Single-neuron NMDA receptor phenotype influences neuronal rewiring and reintegration following traumatic injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Mar 2014
Patel Tapan P, Ventre Scott C, Geddes-Klein Donna, Singh Pallab K, Meaney David F
Abstract excerpt
Alterations in the activity of neural circuits are a common consequence of traumatic brain injury (TBI), but the relationship between single-neuron properties and the aggregate network behavior is not well understood. We recently reported that the GluN2B-containing NMDA receptors (NMDARs) are key in mediating mechanical forces during TBI, and that TBI produces a complex change in the functional connectivity of...
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