Article
A mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase.
The Journal of biological chemistry - 8 Oct 2004
Zhang Xin, Vincent Annette Shoba, Halliwell Barry, Wong Kim Ping
Abstract excerpt
Exposure of Neuro-2a and PC12 cells to micromolar concentrations of sulfite caused an increase in reactive oxygen species and a decrease in ATP. Likewise, the biosynthesis of ATP in intact rat brain mitochondria from the oxidation of glutamate was inhibited by micromolar sulfite. Glutamate-driven respiration increased the mitochondrial membrane potential (MMP), and this was abolished by sulfite but the MMP...
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