Article
Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice.
PloS one - 1 Jan 2013
Renne Ulla, Langhammer Martina, Brenmoehl Julia, Walz Christina, Zeissler Anja, Tuchscherer Armin, Piechotta Marion, Wiesner Rudolf J, Bielohuby Maximilian, Hoeflich Andreas
Abstract excerpt
AIMS/HYPOTHESIS: Visceral obesity holds a central position in the concept of the metabolic syndrome characterized by glucose intolerance in humans. However, until now it is unclear if obesity by itself is responsible for the development of glucose intolerance. METHODS: We have used a novel polygenic mouse model characterized by genetically fixed obesity (DU6) and addressed age- and high fat diet-dependent glucose...
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