Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.

PLoS genetics - 1 May 2006

Koza Robert A, Nikonova Larissa, Hogan Jessica, Rim Jong-Seop, Mendoza Tamra, Faulk Christopher, Skaf Jihad, Kozak Leslie P

Abstract excerpt

High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a molecular model to investigate non-genetic mechanisms of obesity. Feeding mice a high-fat diet beginning at 8 wk of age resulted in a 4-fold difference in adiposity. The phenotypes of mice characteristic of high or low gainers were evident by 6 wk of age, when mice were still on a low-fat diet; they were amplified after...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animal Feed

Share to Behavior, Animal

Share to Body Weight

Share to Energy Metabolism

Share to Feeding Behavior

Share to Intercellular Signaling Peptides and Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16733553
DOI: 10.1371/journal.pgen.0020081
PMCID: PMC1464831

Genes

BMP3
MEST
SFRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Changes in gene expression foreshadow diet-induced obesity in genetically identical mice.PMID 16733553Read ↗

Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat.Semantic proximity Read ↗

Gene expression in normal-weight mice offspring from parents on Western Diets suggests altered risk for obesity and metabolic diseaseSemantic proximity Read ↗

Genetic, metabolic, and molecular insights into the diverse outcomes of diet-induced obesity in miceSemantic proximity Read ↗

The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles.Semantic proximity Read ↗

Characterization of metabolic phenotypes and distinctive genes in mice with low-weight gain.Semantic proximity Read ↗

Genetic background and sex control the outcome of high-fat diet feeding in miceSemantic proximity Read ↗

High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N miceSemantic proximity Read ↗

Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics.Semantic proximity Read ↗

Identification of a specific set of genes predicting obesity before phenotype appearanceSemantic proximity Read ↗

Nutrigenomics of High Fat Diet Induced Obesity in Mice Suggests Relationships between Susceptibility to Fatty Liver Disease and the ProteasomeSemantic proximity Read ↗

Transcript profiling suggests that differential metabolic adaptation of mice to a high fat diet is associated with changes in liver to muscle lipid fluxes.Semantic proximity Read ↗

The early nutritional environment of mice determines the capacity for adipose tissue expansion by modulating genes of caveolae structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.