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Article

High-fat diet induces early-onset diabetes in heterozygous Pax6 mutant mice.

Diabetes/metabolism research and reviews - 1 Sept 2014

Chen Yuanyuan, Feng Ruopeng, Wang Hong, Wei Rui, Yang Jin, Wang Liang, Wang Haining, Zhang Lin, Hong Tian-pei, Wen Jinhua

Abstract excerpt

BACKGROUND: Type 2 diabetes is caused by interactions between genetic and environmental factors. Our previous studies reported that paired box 6 mutation heterozygosity (Pax6(m/+)) led to defective proinsulin processing and subsequent abnormal glucose metabolism in mice at 6 months of age. However, high-fat diet exposure could be an important incentive for diabetes development. In this study, we aimed to develop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24925705
DOI: 10.1002/dmrr.2572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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