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Transgenerational Inheritance of Glucose Intolerance in a Mouse Model of Neonatal Overnutrition

13 Oct 2010

Abstract excerpt

Epidemiological and clinical data show that rapid weight gain early in life is strongly associated with several components of the metabolic syndrome. Strikingly, abnormal growth rates in early life can additionally influence diabetes risk in subsequent generations. Here we aim to study whether neonatal overgrowth induces diabetes in offspring and grand-offspring of affected individuals using a mouse model of...

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Identifiers

PMID: 20943806
DOI: 10.1210/en.2010-0684

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