Article
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.
Communications biology - 3 May 2022
Müller-Eigner Annika, Sanz-Moreno Adrián, de-Diego Irene, Venkatasubramani Anuroop Venkateswaran, Langhammer Martina, Gerlini Raffaele, Rathkolb Birgit, Aguilar-Pimentel Antonio, Klein-Rodewald Tanja, Calzada-Wack Julia, Becker Lore, Palma-Vera Sergio, Gille Benedikt, Forne Ignasi, Imhof Axel, Meng Chen, Ludwig Christina, Koch Franziska, Heiker John T, Kuhla Angela, Caton Vanessa, Brenmoehl Julia, Reyer Henry, Schoen Jennifer, Fuchs Helmut, Gailus-Durner Valerie, Hoeflich Andreas, de Angelis Martin Hrabe, Peleg Shahaf
Abstract excerpt
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world's longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and...
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