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Article

Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice

19 Nov 2008

Abstract excerpt

OBJECTIVE: Low birth weight (LBW) is associated with increased risk of obesity, diabetes, and cardiovascular disease during adult life. Moreover, this programmed disease risk can progress to subsequent generations. We previously described a mouse model of LBW, produced by maternal caloric undernutrition (UN) during late gestation. LBW offspring (F(1)-UN generation) develop progressive obesity and impaired glucose...

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PMID: 19017762
DOI: 10.2337/db08-0490

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