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Conserved Residues of Human XPG Protein Important for Nuclease Activity and Function in Nucleotide Excision Repair

1 Feb 1999

Abstract excerpt

The human XPG endonuclease cuts on the 3' side of a DNA lesion during nucleotide excision repair. Mutations in XPG can lead to the disorders xeroderma pigmentosum (XP) and Cockayne syndrome. XPG shares sequence similarities in two regions with a family of structure-specific nucleases and exonucleases. To begin defining its catalytic mechanism, we changed highly conserved residues and determined the effects on the...

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PMID: 10026181
DOI: 10.1074/jbc.274.9.5637

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Conserved Residues of Human XPG Protein Important for Nuclease Activity and Function in Nucleotide Excision RepairPMID 10026181Read ↗

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