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Article

Survivin-induced abnormal ploidy contributes to cystic kidney and aneurysm formation.

Circulation - 11 Feb 2014

Aboualaiwi Wissam A, Muntean Brian S, Ratnam Shobha, Joe Bina, Liu Lijun, Booth Robert L, Rodriguez Ingrid, Herbert Britney S, Bacallao Robert L, Fruttiger Marcus, Mak Tak W, Zhou Jing, Nauli Surya M

Abstract excerpt

BACKGROUND: Cystic kidneys and vascular aneurysms are clinical manifestations seen in patients with polycystic kidney disease, a cilia-associated pathology (ciliopathy). Survivin overexpression is associated with cancer, but the clinical pathology associated with survivin downregulation or knockout has never been studied before. The present studies aim to examine whether and how cilia function (Pkd1 or Pkd2) and...

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Source

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Identifiers

PMID: 24235270
DOI: 10.1161/CIRCULATIONAHA.113.005746
PMCID: PMC3946000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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