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Article

Primary cilia control endothelial permeability by regulating expression and location of junction proteins

9 May 2021

Abstract excerpt

AIMS: Wall shear stress (WSS) determines intracranial aneurysm (IA) development. Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture. Dysfunction/absence of primary cilia in PKD endothelial cells (ECs) may impair mechano-transduction of WSS and favour vascular disorders. The molecular links between primary cilia dysfunction and IAs are unknown. METHODS AND RESULTS: Wild-type and...

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PMID: 33974072
DOI: 10.1093/cvr/cvab165

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