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Article

Ca2+-independent binding of anionic phospholipids by phospholipase C δ1 EF-hand domain.

The Journal of biological chemistry - 27 Dec 2013

Cai Jingfei, Guo Su, Lomasney Jon W, Roberts Mary F

Abstract excerpt

Recombinant EF-hand domain of phospholipase C δ1 has a moderate affinity for anionic phospholipids in the absence of Ca(2+) that is driven by interactions of cationic and hydrophobic residues in the first EF-hand sequence. This region of PLC δ1 is missing in the crystal structure. The relative orientation of recombinant EF with respect to the bilayer, established with NMR methods, shows that the N-terminal helix...

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Identifiers

PMID: 24235144
DOI: 10.1074/jbc.M113.512186
PMCID: PMC3873580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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