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Article

Crystal structure and allosteric activation of protein kinase C βII.

Cell - 7 Jan 2011

Leonard Thomas A, Różycki Bartosz, Saidi Layla F, Hummer Gerhard, Hurley James H

Abstract excerpt

Protein kinase C (PKC) isozymes are the paradigmatic effectors of lipid signaling. PKCs translocate to cell membranes and are allosterically activated upon binding of the lipid diacylglycerol to their C1A and C1B domains. The crystal structure of full-length protein kinase C βII was determined at 4.0 Å, revealing the conformation of an unexpected intermediate in the activation pathway. Here, the kinase active...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21215369
DOI: 10.1016/j.cell.2010.12.013
PMCID: PMC3104240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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