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Article

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study.

Clinical pharmacokinetics - 1 Mar 2014

Kloth Jacqueline S L, Klümpen Heinz-Josef, Yu Huixin, Eechoute Karel, Samer Caroline F, Kam Boen L R, Huitema Alwin D R, Daali Youssef, Zwinderman Aeilko H, Balakrishnar Bavanthi, Bennink Roelof J, Wong Mark, Schellens Jan H M, Mathijssen Ron H J, Gurney Howard

Abstract excerpt

BACKGROUND AND OBJECTIVE: The wide inter-patient variability in drug exposure partly explains the toxicity and efficacy profile of sunitinib treatment. In this prospective study cytochrome P450 (CYP) 3A and adenosine triphosphate binding cassette (ABC) B1 phenotypes were correlated to the pharmacokinetics of sunitinib and its active metabolite N-desethylsunitinib. METHODS: A correlation analysis was performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24234588
DOI: 10.1007/s40262-013-0111-4

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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