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Genetic polymorphisms of VEGFR2 and FGFR2 genes are associated with exposure to sunitinib and cardiovascular toxicity.

Pharmacogenomics - 1 Jan 2025

Mbatchi Litaty C, Leenhardt Fanny, Occean Bob-Valéry, Perrin Olivier, Boyer Jean-Christophe, Gongora Céline, Pourquier Philippe, Mura Thibault, Chapelle Angélique, Topart Delphine, Evrard Alexandre, Houede Nadine

Abstract excerpt

PURPOSE: Sunitinib is a multikinase inhibitor used to treat metastatic renal cell carcinoma (mRCC), with an inter-individual variability of pharmacokinetics and toxicity. Our goal was to assess associations between the pharmacogenetics, pharmacokinetics and toxicity of sunitinib. METHODS: In this multi-center prospective study, 42 patients with mRCC were included. An NGS panel was used to identify variations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41277563
DOI: 10.1080/14622416.2025.2579001
PMCID: PMC12667618

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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