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Article

SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells

14 Nov 2013

Abstract excerpt

Previous studies have implicated cancer stem cells in tumor recurrence and revealed that the stem cell gene SOX2 plays an important role in the tumor cell resistance to apoptosis. Nonetheless, the mechanism by which SOX2 regulates apoptosis signals remained undefined. Here, we demonstrated the surprising finding that silencing of the SOX2 gene effectively induces apoptosis via the activation of death receptor and...

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PMID: 24233838
DOI: 10.1093/carcin/bgt371

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