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Article

Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer.

BMC cancer - 19 Jan 2016

Samulin Erdem Johanna, Skaug Vidar, Bakke Per, Gulsvik Amund, Haugen Aage, Zienolddiny Shanbeh

Abstract excerpt

BACKGROUND: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC). SOX2 signaling is important in maintaining the stem cell-like phenotype of cancer cells and contributes to the pathogenesis of lung cancer. TP53 is known to inhibit gene amplifications and to repress many stem cell-associated genes following DNA damage. The aim of...

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Share to Carcinoma, Non-Small-Cell Lung
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Silencing

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Share to SOXB1 Transcription Factors

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 26780934
DOI: 10.1186/s12885-016-2061-3
PMCID: PMC4717590

Genes

SOX2
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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