Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors

10 Jul 2023

Abstract excerpt

This study investigates the role of integrin β4 (ITGB4) and stemness-associated factor SOX2 in platinum resistance in lung squamous cell carcinoma (LUSC). The expression of SOX2 and ITGB4 is found to be high in all LUSC subtypes, but the impact of ITGB4 expression on overall patient survival varies by subtype. Cancer stem cells (CSCs) isolated from LUSC patients were found to be resistant to cisplatin, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lung Cancer Research Studies
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37554452
DOI: 10.1016/j.isci.2023.107302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitorsPMID 37554452Read ↗

SOX2 in cancer stemness: tumor malignancy and therapeutic potentialsSemantic proximity Read ↗

The role of SOX2 in small cell lung cancer, lung adenocarcinoma and squamous cell carcinoma of the lung.Semantic proximity Read ↗

The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung CancerSemantic proximity Read ↗

Single-Cell Transcriptomics Unveils the Dedifferentiation Mechanism of Lung Adenocarcinoma Stem CellsSemantic proximity Read ↗

Lung cancer stem cells: The root of resistance.Semantic proximity Read ↗

Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2Semantic proximity Read ↗

The SOX9-Aldehyde Dehydrogenase Axis Determines Resistance to Chemotherapy in Non-Small-Cell Lung CancerSemantic proximity Read ↗

B4GALT1 Is a New Candidate to Maintain the Stemness of Lung Cancer Stem CellsSemantic proximity Read ↗

SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancerSemantic proximity Read ↗

ZIC2 promotes cancer stem cell traits via up-regulating OCT4 expression in lung adenocarcinoma cellsSemantic proximity Read ↗

SHP2 inhibition enhances the anticancer effect of Osimertinib in EGFR T790M mutant lung adenocarcinoma by blocking CXCL8 loop mediated stemnessSemantic proximity Read ↗

TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemnessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.