Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-talk between SOX2 and TGFβ Signaling Regulates EGFR-TKI Tolerance and Lung Cancer Dissemination.

Cancer research - 15 Oct 2020

Kuo Ming-Han, Lee An-Chun, Hsiao Shih-Hsin, Lin Sey-En, Chiu Yu-Fan, Yang Li-Hao, Yu Chia-Cherng, Chiou Shih-Hwa, Huang Hsien-Neng, Ko Jen-Chung, Chou Yu-Ting

Abstract excerpt

Regulation of the stemness factor, SOX2, by cytokine stimuli controls self-renewal and differentiation in cells. Activating mutations in EGFR are proven therapeutic targets for tyrosine kinase inhibitors (TKI) in lung adenocarcinoma, but acquired resistance to TKIs inevitably occurs. The mechanism by which stemness and differentiation signaling emerge in lung cancers to affect TKI tolerance and lung cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Epithelial-Mesenchymal Transition

Share to Protein Kinase Inhibitors

Share to SOXB1 Transcription Factors

Share to Transforming Growth Factor beta

Share to Vimentin

Source

Identifiers

PMID: 32816907
DOI: 10.1158/0008-5472.CAN-19-3228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-talk between SOX2 and TGFβ Signaling Regulates EGFR-TKI Tolerance and Lung Cancer Dissemination.PMID 32816907Read ↗

The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung CancerSemantic proximity Read ↗

Repression of TIF1γ by SOX2 promotes TGF-β-induced epithelial–mesenchymal transition in non-small-cell lung cancerSemantic proximity Read ↗

SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines.Semantic proximity Read ↗

Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitorsSemantic proximity Read ↗

SOX2 Promotes Radioresistance in Non-small Cell Lung Cancer by Regulating Tumor Cells DedifferentiationSemantic proximity Read ↗

The Role of Mesenchymal Stem Cells in Drug Resistance in Lung NeoplasmsSemantic proximity Read ↗

The role of SOX2 in small cell lung cancer, lung adenocarcinoma and squamous cell carcinoma of the lung.Semantic proximity Read ↗

SOX2 Gene Regulates the Transcriptional Network of Oncogenes and Affects Tumorigenesis of Human Lung Cancer CellsSemantic proximity Read ↗

SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cellsSemantic proximity Read ↗

TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemnessSemantic proximity Read ↗

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of OriginSemantic proximity Read ↗

Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.