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Article

SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity.

Laboratory investigation; a journal of technical methods and pathology - 1 Dec 2011

Nakatsugawa Munehide, Takahashi Akari, Hirohashi Yoshihiko, Torigoe Toshihiko, Inoda Satoko, Murase Masaki, Asanuma Hiroko, Tamura Yasuaki, Morita Rena, Michifuri Yoshitaka, Kondo Toru, Hasegawa Tadashi, Takahashi Hiroki, Sato Noriyuki

Abstract excerpt

Recently, the SOX2 gene has been reported to be amplified in human lung squamous cell carcinomas. However, its roles in human lung adenocarcinomas are still elusive. In this study, we analyzed the functions of SOX2 in cancer stem-like cells (CSCs)/cancer-initiating cells (CICs) derived from human lung adenocarcinoma. Human lung CSCs/CICs were isolated as higher tumorigenic side population (SP) cells using Hoechst...

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Source

Identifiers

PMID: 21931300
DOI: 10.1038/labinvest.2011.140

Genes

SOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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