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Article

The role of CD8<sup>+</sup> T‐cell replicative senescence in human aging

9 May 2005

Abstract excerpt

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity. CD8(+) T cells that undergo extensive rounds of antigen-driven proliferation in cell culture invariably reach the end stage of replicative senescence, characterized by irreversible cell-cycle...

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PMID: 15882351
DOI: 10.1111/j.0105-2896.2005.00259.x

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