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Article

Replicative Senescence: The Final Stage of Memory T Cell Differentiation?

1 Apr 2003

Abstract excerpt

One of the major obstacles to effective prolonged CD8 T cell control over HIV and other latent infections may be the intrinsic, genetically programmed barrier to unlimited proliferation that is characteristic of all normal human somatic cells. Replicative senescence, characterized extensively in cell culture for a variety of cell types, comprises both irreversible cell cycle arrest and striking changes in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15043200
DOI: 10.2174/1570162033485348

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