Article
Activation of microglial neuregulin1 signaling in the corticospinal tracts of ALS patients with upper motor neuron signs.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Mar 2014
Song Fei, Chiang Pohung, Ravits John, Loeb Jeffrey A
Abstract excerpt
We recently found neuregulin1 (NRG1) receptors are activated on microglia in the ventral horn of both ALS patients and SOD1 mice, suggesting a common pathological mechanism. However, it is not clear whether this signaling system also plays a role in patients with upper motor neuron (UMN) features, where patients show significant pathological changes in the corticospinal tracts (CSTs). Since the connection between...
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