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Article

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.

Acta neuropathologica communications - 18 Feb 2016

Lasiene Jurate, Komine Okiru, Fujimori-Tonou Noriko, Powers Berit, Endo Fumito, Watanabe Seiji, Shijie Jin, Ravits John, Horner Philip, Misawa Hidemi, Yamanaka Koji

Abstract excerpt

INTRODUCTION: Increasing evidence implicates the role of the cell types surrounding motor neurons, such as interneurons and glial cells, in non-cell autonomous neurodegeneration of amyotrophic lateral sclerosis (ALS). C-boutons, the large cholinergic synapses that innervate spinal α-motor neurons to control their excitability, are progressively lost from motor neurons in both human ALS and mutant Cu/Zn superoxide...

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Identifiers

PMID: 26891847
DOI: 10.1186/s40478-016-0286-7
PMCID: PMC4758105

Genes

NRG1
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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