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Article

Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes.

Thrombosis and haemostasis - 3 Mar 2014

Segers O, Simioni P, Tormene D, Castoldi E

Abstract excerpt

Carriership of the factor V (FV) Leiden mutation increases the risk of venous thromboembolism (VTE) ~4-fold, but the individual risk of each FV Leiden carrier depends on several co-inherited risk and protective factors. Under the hypothesis that thrombin generation might serve as an intermediate phenotype to identify genetic modulators of VTE risk, we enrolled 188 FV Leiden heterozygotes (11 with VTE) and...

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Identifiers

PMID: 24226152
DOI: 10.1160/TH13-05-0360

Genes

APC
PROS1
SERPINC1
TFPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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