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Article

Genetic modulation of the FV(Leiden)/normal FV ratio and risk of venous thrombosis in factor V Leiden heterozygotes.

Journal of thrombosis and haemostasis : JTH - 1 Jan 2012

Segers O, Simioni P, Tormene D, Bulato C, Gavasso S, Rosing J, Castoldi Elisabetta

Abstract excerpt

BACKGROUND AND OBJECTIVES: The factor (F)V Leiden mutation causes activated protein C (APC) resistance by decreasing the susceptibility of FVa to APC-mediated inactivation and by impairing the APC-cofactor activity of FV in FVIIIa inactivation. However, APC resistance and the risk of venous thromboembolism (VTE) vary widely among FV Leiden heterozygotes. Common F5 genetic variation probably contributes to this...

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Identifiers

PMID: 22044617
DOI: 10.1111/j.1538-7836.2011.04546.x

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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