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Article

Classic Thrombophilias and Thrombotic Risk Among Middle-Aged and Older Adults: A Population-Based Cohort Study.

Journal of the American Heart Association - 15 Feb 2022

Manderstedt Eric, Lind-Halldén Christina, Halldén Christer, Elf Johan, Svensson Peter J, Dahlbäck Björn, Engström Gunnar, Melander Olle, Baras Aris, Lotta Luca A, Zöller Bengt

Abstract excerpt

Background Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle-aged and older adults. Methods and Results Factor V Leiden, prothrombin G20210A and protein-coding variants in the PROC (protein...

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Identifiers

PMID: 35112923
DOI: 10.1161/JAHA.121.023018
PMCID: PMC9245807

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