Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence.

Journal of psychopharmacology (Oxford, England) - 1 May 2021

Sebold Miriam, Garbusow Maria, Cerci Deniz, Chen Ke, Sommer Christian, Huys Quentin Jm, Nebe Stephan, Rapp Michael, Veer Ilya M, Zimmermann Ulrich S, Smolka Michael N, Walter Henrik, Heinz Andreas, Friedel Eva

Abstract excerpt

BACKGROUND: Pavlovian-to-instrumental transfer (PIT) quantifies the extent to which a stimulus that has been associated with reward or punishment alters operant behaviour. In alcohol dependence (AD), the PIT effect serves as a paradigmatic model of cue-induced relapse. Preclinical studies have suggested a critical role of the opioid system in modulating Pavlovian-instrumental interactions. The A118G polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alcoholism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Motivation

Share to Polymorphism, Single Nucleotide

Share to Receptors, Opioid, mu

Share to Recurrence

Share to Reward

Source

Open in PubMed Open full text

Identifiers

PMID: 33726538
DOI: 10.1177/0269881121991992
PMCID: PMC8155738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the OPRM1 A118G polymorphism and Pavlovian-to-instrumental transfer: Clinical relevance for alcohol dependence.PMID 33726538Read ↗

Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.Semantic proximity Read ↗

The OPRM1 A118G polymorphism: converging evidence against associations with alcohol sensitivity and consumption.Semantic proximity Read ↗

Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans.Semantic proximity Read ↗

Alcohol Consumption in Healthy OPRM1 G Allele Carriers and Its Association with Impulsive Behavior.Semantic proximity Read ↗

Initial evidence of an association between OPRM1 and adolescent alcohol misuse.Semantic proximity Read ↗

The OPRM1 A118G G Allele Is Associated With Poorer Auditory-Verbal Learning and Memory, Executive Functions, and Working Memory in Veterans Undergoing Residential Treatment for Alcohol Use Disorder.Semantic proximity Read ↗

Recovery profiles from reward downshift are correlated with operant licking maintained by alcohol, but not with genetic variation in the mu opioid receptor.Semantic proximity Read ↗

Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.Semantic proximity Read ↗

Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: a functional imaging study in alcohol dependent subjects.Semantic proximity Read ↗

A functional polymorphism of the mu-opioid receptor gene (OPRM1) influences cue-induced craving for alcohol in male heavy drinkers.Semantic proximity Read ↗

Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.Semantic proximity Read ↗

Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.