Article
Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian Population.
International journal of molecular sciences - 28 May 2026
Buianova Anastasiia A, Cheranev Valery V, Shmitko Anna O, Vasiliadis Iuliia A, Samitova Alina F, Suchalko Oleg N, Repinskaia Zhanna A, Kuznetsov Mikhail Iu, Belova Vera A, Korostin Dmitriy O
Abstract excerpt
Adverse drug reactions (ADRs) remain a major public health issue, and genetic factors contribute importantly to interindividual variability in drug response. Pharmacogenetic testing helps reduce ADR risk by optimizing drug selection and dosage, particularly in monogenic disorders. Whole-exome sequencing of 6739 samples from the Russian population was performed on the DNBSEQ-G400 platform (MGI). Variants in 48...
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