Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes.

American heart journal - 1 Dec 2006

Mank-Seymour Amy R, Richmond Jodi L, Wood Linda S, Reynolds Jennifer M, Fan Yu-Ti, Warnes Gregory R, Milos Patrice M, Thompson John F

Abstract excerpt

BACKGROUND: Reduction of drug-induced adverse events may be achievable through a better understanding of the underlying causes of such events. Identifying phenotypes and genotypes that allow event prediction would provide greater safety margins for new therapeutics. Torsades de pointes (TdP) is one such life-threatening adverse event and can arise from excessive lengthening of the QT interval. This study was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Ankyrins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to KCNQ1 Potassium Channel

Share to Long QT Syndrome

Share to Muscle Proteins

Share to NAV1.5 Voltage-Gated Sodium Channel

Share to Sodium Channels

Share to Torsades de Pointes

Source

Identifiers

PMID: 17161064
DOI: 10.1016/j.ahj.2006.08.020

Genes

ANK2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of torsades de pointes with novel and known single nucleotide polymorphisms in long QT syndrome genes.PMID 17161064Read ↗

Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes.Semantic proximity Read ↗

Targeted mutational analysis of ankyrin-B in 541 consecutive, unrelated patients referred for long QT syndrome genetic testing and 200 healthy subjects.Semantic proximity Read ↗

Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome.Semantic proximity Read ↗

Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.Semantic proximity Read ↗

Genetic variations of KCNQ1, KCNH2, SCN5A, KCNE1, and KCNE2 in drug-induced long QT syndrome patients.Semantic proximity Read ↗

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study.Semantic proximity Read ↗

A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes.Semantic proximity Read ↗

Association of the NOS1AP rs10494366 Genetic Variant With Drug-Induced QT Prolongation.Semantic proximity Read ↗

Drug-induced torsades de pointes: the evolving role of pharmacogenetics.Semantic proximity Read ↗

Monogenic Syndromes as a Cause of Adverse Drug Reactions in the Russian PopulationSemantic proximity Read ↗

Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome.Semantic proximity Read ↗

Common genetic variants in ANK2 modulate QT interval: results from the KORA study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.