Article
Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans.
Clinical pharmacology and therapeutics - 1 Jun 2000
Xie H G, Stein C M, Kim R B, Gainer J V, Sofowora G, Dishy V, Brown N J, Goree R E, Haines J L, Wood A J
Abstract excerpt
BACKGROUND AND OBJECTIVES: The most common polymorphisms of the human beta2-adrenergic receptor--Arg16-->Gly and Gln27-->Glu--are associated with alterations in beta2-adrenergic receptor responses, both in vitro and in vivo. beta2-Adrenergic receptor-mediated vascular responses are affected by ethnicity, blood pressure, and genotype. We tested the hypothesis that these two common beta2-adrenergic receptor genetic...
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