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Article

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells.

Journal of experimental & clinical cancer research : CR - 7 Oct 2013

Garufi Alessia, Trisciuoglio Daniela, Porru Manuela, Leonetti Carlo, Stoppacciaro Antonella, D'Orazi Valerio, Avantaggiati Maria, Crispini Alessandra, Pucci Daniela, D'Orazi Gabriella

Abstract excerpt

BACKGROUND: Mutations of the p53 oncosuppressor gene are amongst the most frequent aberration seen in human cancer. Some mutant (mt) p53 proteins are prone to loss of Zn(II) ion that is bound to the wild-type (wt) core, promoting protein aggregation and therefore unfolding. Misfolded p53 protein conformation impairs wtp53-DNA binding and transactivation activities, favouring tumor growth and resistance to...

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Identifiers

PMID: 24220325
DOI: 10.1186/1756-9966-32-72
PMCID: PMC3851540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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