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Article

Mutant p53 rescue and modulation of p53 redox state.

Cell cycle (Georgetown, Tex.) - 15 Aug 2009

Bykov Vladimir J N, Lambert Jeremy M R, Hainaut Pierre, Wiman Klas G

Abstract excerpt

The p53 tumor suppressor is a key regulator of cell growth and survival upon various forms of cellular stress. p53 is a redox-regulated transcription factor that binds specifically to DNA and activates transcription of target genes. The core domain of p53 holds a zinc atom that protects p53 from oxidation and is critical for DNA binding. A large fraction of human tumors carry p53 mutation, allowing evasion of...

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Identifiers

PMID: 19633417
DOI: 10.4161/cc.8.16.9382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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