Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metal-Based Anticancer Complexes and p53: How Much Do We Know?

19 May 2023

Abstract excerpt

P53 plays a key role in protecting the human genome from DNA-related mutations; however, it is one of the most frequently mutated genes in cancer. The P53 family members p63 and p73 were also shown to play important roles in cancer development and progression. Currently, there are various organic molecules from different structural classes of compounds that could reactivate the function of wild-type p53, degrade...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to MicroRNA in disease regulation
Share to Trace Elements in Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37345171
DOI: 10.3390/cancers15102834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metal-Based Anticancer Complexes and p53: How Much Do We Know?PMID 37345171Read ↗

A role for bioinorganic chemistry in the reactivation of mutant p53 in cancer.Semantic proximity Read ↗

An overview of the functions of p53 and drugs acting either on wild- or mutant-type p53.Semantic proximity Read ↗

Mutant p53 rescue and modulation of p53 redox state.Semantic proximity Read ↗

Recent findings on the role of wild-type and mutant p53 in cancer development and therapySemantic proximity Read ↗

Zn(II)-curc targets p53 in thyroid cancer cells.Semantic proximity Read ↗

Discovery of Drugs Targeting Mutant p53 and Progress in Nano-Enabled Therapeutic Strategy for p53-Mutated Cancers.Semantic proximity Read ↗

Unravelling the Anticancer Potential of a Square Planar Copper Complex: Toward Non-platinum ChemotherapySemantic proximity Read ↗

Metal ions as regulators of the conformation and function of the tumour suppressor protein p53: implications for carcinogenesis.Semantic proximity Read ↗

The Undervalued Avenue to Reinstate Tumor Suppressor Functionality of the p53 Protein Family for Improved Cancer Therapy - Drug RepurposingSemantic proximity Read ↗

[Advances on mutant p53 research].Semantic proximity Read ↗

The role of the tumor suppressor p53 pathway in the cellular DNA damage response to zinc oxide nanoparticlesSemantic proximity Read ↗

p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.