Article
Degradation of mutant p53H175 protein by Zn(II) through autophagy.
Cell death & disease - 29 May 2014
Garufi A, Pucci D, D'Orazi V, Cirone M, Bossi G, Avantaggiati M L, D'Orazi G
Abstract excerpt
TP53, one of the most important oncosuppressors, is frequently mutated in cancer. Several p53 mutant proteins escape proteolytic degradation and are highly expressed in an aberrant conformation often acquiring pro-oncogenic activities that promote tumor progression and resistance to therapy. Therefore, it has been vastly proposed that reactivation of wild-type (wt) function(s) from mutant p53 (mutp53) may have...
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