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Article

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

Cell cycle (Georgetown, Tex.) - 15 May 2011

Puca Rosa, Nardinocchi Lavinia, Porru Manuela, Simon Amos J, Rechavi Gideon, Leonetti Carlo, Givol David, D'Orazi Gabriella

Abstract excerpt

Absence of p53 expression or expression of mutant p53 (mtp53) are common in human cancers and are associated with increased cancer resistance to chemo- and radiotherapy. Therefore, significant efforts towards pharmaceutical reactivation of defective p53 pathways are underway. We previously report...

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Source

Identifiers

PMID: 21508668
DOI: 10.4161/cc.10.10.15642

Genes

HIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21508668-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.PMID 21508668Read ↗

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