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Article

A role for bioinorganic chemistry in the reactivation of mutant p53 in cancer.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry - 1 Aug 2022

Miller Jessica J, Kwan Kalvin, Gaiddon Christian, Storr Tim

Abstract excerpt

Metal ion dysregulation has been implicated in a number of diseases from neurodegeneration to cancer. While defective metal ion transport mechanisms are known to cause specific diseases of genetic origin, the role of metal dysregulation in many diseases has yet to be elucidated due to the complicated function (both good and bad!) of metal ions in the body. A breakdown in metal ion speciation can manifest in...

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PMID: 35488931
DOI: 10.1007/s00775-022-01939-2

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