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Article

Dense and pleiotropic regulatory information in a developmental enhancer.

Nature - 1 Nov 2020

Fuqua Timothy, Jordan Jeff, van Breugel Maria Elize, Halavatyi Aliaksandr, Tischer Christian, Polidoro Peter, Abe Namiko, Tsai Albert, Mann Richard S, Stern David L, Crocker Justin

Abstract excerpt

Changes in gene regulation underlie much of phenotypic evolution1. However, our understanding of the potential for regulatory evolution is biased, because most evidence comes from either natural variation or limited experimental perturbations2. Using an automated robotics pipeline, we surveyed an unbiased mutation library for a developmental enhancer in Drosophila melanogaster. We found that almost all mutations...

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Identifiers

PMID: 33057197
DOI: 10.1038/s41586-020-2816-5
PMCID: PMC8236315

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