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Article

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Proceedings of the National Academy of Sciences of the United States of America - 22 Sept 2015

Prusiner Stanley B, Woerman Amanda L, Mordes Daniel A, Watts Joel C, Rampersaud Ryan, Berry David B, Patel Smita, Oehler Abby, Lowe Jennifer K, Kravitz Stephanie N, Geschwind Daniel H, Glidden David V, Halliday Glenda M, Middleton Lefkos T, Gentleman Steve M, Grinberg Lea T, Giles Kurt

Abstract excerpt

Prions are proteins that adopt alternative conformations that become self-propagating; the PrP(Sc) prion causes the rare human disorder Creutzfeldt-Jakob disease (CJD). We report here that multiple system atrophy (MSA) is caused by a different human prion composed of the α-synuclein protein. MSA...

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Identifiers

PMID: 26324905
DOI: 10.1073/pnas.1514475112
PMCID: PMC4586853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-26324905-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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