Article
Abnormal metabolic phenotype in middle-aged GH-deficient adults despite long-term recombinant human GH replacement.
European journal of endocrinology - 1 Feb 2014
Claessen K M J A, Appelman-Dijkstra N M, Pereira A M, Joustra S D, de Mutsert R, Gast K B, den Heijer M, Smit J W A, Dekkers O M, Biermasz N R
Abstract excerpt
BACKGROUND: Adult GH deficiency (GHD) is associated with increased cardiovascular mortality. Recombinant human GH (rhGH) replacement has beneficial short-term metabolic effects. Although these positive effects sustain during longer follow-up, the prevalence of the metabolic syndrome (MS) remains increased in comparison with population data not adjusted for the higher mean BMI in GHD adults. OBJECTIVE: To explore...
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