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Article

Influence of the d3-growth hormone (GH) receptor isoform on short-term and long-term treatment response to GH replacement in GH-deficient adults.

The Journal of clinical endocrinology and metabolism - 1 Jul 2008

van der Klaauw Agatha A, van der Straaten Tahar, Baak-Pablo Renee, Biermasz Nienke R, Guchelaar Henk-Jan, Pereira Alberto M, Smit Johannes W A, Romijn Johannes A

Abstract excerpt

OBJECTIVE: Recombinant human GH (rhGH) replacement in adults is aimed at improving signs and symptoms of the adult GH deficiency (GHD) syndrome. In children, a common polymorphism of the GH receptor (exon-3 deletion, d3GHR) increases the response to rhGH replacement. The aim of this study was to assess the effects of this polymorphism on the response to rhGH replacement in adults. DESIGN: Prospective intervention...

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Source

Identifiers

PMID: 18397980
DOI: 10.1210/jc.2007-2728

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Influence of the d3-growth hormone (GH) receptor isoform on short-term and long-term treatment response to GH replacement in GH-deficient adults.PMID 18397980Read ↗

Influence of the d3GH receptor polymorphism on the metabolic and biochemical phenotype of GH-deficient adults at baseline and during short- and long-term recombinant human GH replacement therapy.Semantic proximity Read ↗

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The prevalence of polymorphism of exon 3 expression of the growth hormone receptor gene in the general population and its influence on quality of life, body composition and response to growth hormone replacement in growth hormone deficient adultsSemantic proximity Read ↗

Influence of growth hormone (GH) receptor deletion of exon 3 and full-length isoforms on GH response and final height in patients with severe GH deficiency.Semantic proximity Read ↗

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The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy.Semantic proximity Read ↗

Influence of the exon 3 deletion of GH receptor and IGF-I level at diagnosis on the efficacy and safety of treatment with somatotropin in adults with GH deficiency.Semantic proximity Read ↗

The Growth Response to Growth Hormone (GH) Treatment in Children with Isolated GH Deficiency Is Independent of the Presence of the Exon 3-Minus Isoform of the GH ReceptorSemantic proximity Read ↗

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d3-GHR genotype does not explain heterogeneity in GH responsiveness in hypopituitary adults.Semantic proximity Read ↗

The Leu544Ile polymorphism of the growth hormone receptor gene affects the serum cholesterol levels during GH treatment in children with GH deficiency.Semantic proximity Read ↗

Common Polymorphisms of the Growth Hormone (GH) Receptor Do Not Correlate with the Growth Response to Exogenous Recombinant Human GH in GH-Deficient ChildrenSemantic proximity Read ↗

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