Article
Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.
European journal of endocrinology - 1 Sept 2012
Barbosa Edna J L, Glad Camilla A M, Nilsson Anna G, Filipsson Nyström Helena, Götherström Galina, Svensson Per-Arne, Vinotti Isabela, Bengtsson Bengt-Åke, Nilsson Staffan, Boguszewski Cesar Luiz, Johannsson Gudmundur
Abstract excerpt
OBJECTIVE: GH deficiency (GHD) in adults is associated with an altered serum lipid profile that responds to GH replacement therapy (GHRT). This study evaluated the influence of polymorphisms in genes related to lipid metabolism on serum lipid profile before and after 1 year of GHRT in adults. DESIGN AND METHODS: In 318 GHD patients, total cholesterol (TC) serum concentrations, LDL-C, HDL-C, and triglycerides (TG)...
Topics
- Adolescent
- Adult
- Aged
- Cohort Studies
- Dwarfism, Pituitary
- Female
- Genetic Variation
- Genotype
- Human Growth Hormone
- Humans
- Lipid Metabolism
- Lipids
- Longitudinal Studies