Article
Influence of the d3GH receptor polymorphism on the metabolic and biochemical phenotype of GH-deficient adults at baseline and during short- and long-term recombinant human GH replacement therapy.
European journal of endocrinology - 1 Sept 2010
Giavoli Claudia, Ferrante Emanuele, Profka Eriselda, Olgiati Luca, Bergamaschi Silvia, Ronchi Cristina L, Verrua Elisa, Filopanti Marcello, Passeri Elena, Montefusco Laura, Lania Andrea G, Corbetta Sabrina, Arosio Maura, Ambrosi Bruno, Spada Anna, Beck-Peccoz Paolo
Abstract excerpt
OBJECTIVE: A common polymorphic variant of GH receptor (exon 3 deletion, d3GHR) has been linked with increased response to recombinant human GH (rhGH) in some patients with or without GH deficiency (GHD). The aim of the study was to investigate the impact of the GHR genotype on the phenotype of GHD adults and on the metabolic effect of rhGH therapy. DESIGN: Prospective study of GHD patients evaluated before and...
Topics
- Adult
- Age Factors
- Drug Administration Schedule
- Dwarfism, Pituitary
- Female
- Gene Deletion
- Human Growth Hormone
- Humans
- Male