Article
The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature.
Science advances - 1 Jun 2017
Ben-Avraham Danny, Govindaraju Diddahally R, Budagov Temuri, Fradin Delphine, Durda Peter, Liu Bing, Ott Sandy, Gutman Danielle, Sharvit Lital, Kaplan Robert, Bougnères Pierre, Reiner Alex, Shuldiner Alan R, Cohen Pinchas, Barzilai Nir, Atzmon Gil
Abstract excerpt
Although both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling were shown to regulate life span in lower organisms, the role of GH signaling in human longevity remains unclear. Because a GH receptor exon 3 deletion (d3-GHR) appears to modulate GH sensitivity in humans, we hypothesized that this polymorphism could play a role in human longevity. We report a linear increased prevalence of...
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