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Article

Common polymorphisms in human langerin change specificity for glycan ligands.

The Journal of biological chemistry - 27 Dec 2013

Feinberg Hadar, Rowntree Thomas J W, Tan Shawn L W, Drickamer Kurt, Weis William I, Taylor Maureen E

Abstract excerpt

Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake of pathogens in the first step of antigen presentation to the adaptive immune system. Langerin binds a diverse range of carbohydrates including high mannose structures, fucosylated blood group antigens, and glycans with terminal 6-sulfated galactose. Mutagenesis and quantitative binding assays indicate that salt bridges between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lectins, C-Type

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Identifiers

PMID: 24217250
DOI: 10.1074/jbc.M113.528000
PMCID: PMC3873535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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