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Article

Polymorphisms in human langerin affect stability and sugar binding activity.

The Journal of biological chemistry - 2 Jun 2006

Ward Eliot M, Stambach Nicola S, Drickamer Kurt, Taylor Maureen E

Abstract excerpt

Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment tha...

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Source

Identifiers

PMID: 16567809
DOI: 10.1074/jbc.M511502200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-16567809-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Polymorphisms in human langerin affect stability and sugar binding activity.PMID 16567809Read ↗

Common polymorphisms in human langerin change specificity for glycan ligands.Semantic proximity Read ↗

Langerin functions as an antiviral receptor on Langerhans cellsSemantic proximity Read ↗

Alteration of the langerin oligomerization state affects Birbeck granule formation.Semantic proximity Read ↗

A Lack of Birbeck Granules in Langerhans Cells Is Associated with a Naturally Occurring Point Mutation in the Human Langerin GeneSemantic proximity Read ↗

Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.Semantic proximity Read ↗

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Single-nucleotide polymorphisms in porcine mannan-binding lectin A.Semantic proximity Read ↗

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