Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in human langerin affect stability and sugar binding activity.

The Journal of biological chemistry - 2 Jun 2006

Ward Eliot M, Stambach Nicola S, Drickamer Kurt, Taylor Maureen E

Abstract excerpt

Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells. Langerin binds and mediates uptake and degradation of glycoconjugates containing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Cattle
Share to Galactose

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Langerhans Cells

Share to Lectins, C-Type

Share to Mannose

Share to Mannose-Binding Lectins

Source

Identifiers

PMID: 16567809
DOI: 10.1074/jbc.M511502200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Polymorphisms in human langerin affect stability and sugar binding activity.PMID 16567809Read ↗

Common polymorphisms in human langerin change specificity for glycan ligands.Semantic proximity Read ↗

Langerin functions as an antiviral receptor on Langerhans cellsSemantic proximity Read ↗

Alteration of the langerin oligomerization state affects Birbeck granule formation.Semantic proximity Read ↗

A Lack of Birbeck Granules in Langerhans Cells Is Associated with a Naturally Occurring Point Mutation in the Human Langerin GeneSemantic proximity Read ↗

Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function.Semantic proximity Read ↗

Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil.Semantic proximity Read ↗

Single-nucleotide polymorphisms in porcine mannan-binding lectin A.Semantic proximity Read ↗

Genetic variants of the mannan-binding lectin are associated with immune reactivity to mannans in Crohn's disease.Semantic proximity Read ↗

Association of deficiency for mannan-binding lectin with anti-mannan antibodies in Crohn's disease: a family study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.